|
|
|
|
In a double-blind placebo-controlled study,we evaluated the effects of clozapine(75 to 250 mg/day,mean 170.8)on dopaminomimetic psychosis and parkinsonian disability.Clozapine prevented deterioration of psychosis during the increase of dopaminomimetics in the 3 patients who completed the study.Worsening of parkinsonism occurred in 3 of the 6 patients.In the dosage used,clozapine's usefulness was limited by its propensity to produce sedation,confusion,and increased parkinsonism. |
|